lunes, 8 de septiembre de 2014

Human nutrition and health


1. What is nutrient?

  Nutrient is a chemical substance found in foods and used in the human body. Nutrients gives you energy, strengthen your bones and muscles and even protect you from getting disease. There are two different types of nutrients that you must be aware of: essential nutrient and non-essential nutrient


  Essential nutrients are the nutrients that cannot be synthesized by your body and thus has to be consumed from food intake. On the other hand, there is a few nutrients that are not essential. Non essential nutrients can be synthesized in the body from other nutrients or found from alternative sources. Yet, if they are involved in diet, the need for biosynthesis of non essential nutrients is diminished.

Essential nutrients
Non-essential nutrients
1.         Water
2.         Some of fatty acids
e.g. omega-3 linoleic acid and omega-6 linoleic acid
3.         Some vitamins
e.g. A, some B vitamins, C, D, folate
4.        Dietary minerals
e.g. iron, potassium, sodium, calcium, phosphorous and iodine
5.         Some amino acids
e.g. phenylalanine and methionine
6.         Carbohydrates
(but energy can come from other sources such as lipids and proteins)
7.         Other lipids and fatty acids
8.         Other vitamins
9.         Other minerals
10.       Other amino acids






  Then how are the non-essential nutrients synthesized in the body? Out of twenty different amino acids, eleven of them are non essential meaning they can be synthesized in the body from other nutrients. Yet, the human body will only expend the energy required for their biosynthesis if they cannot be derived from the diet.

*Biosynthesis: production of non essential nutrients in the body from components of essential nutrients

2. Protein deficiency malnutrition

Protein deficiency malnutrition is caused by inadequate supply of one or more essential amino acids and it is the key factor of ‘kwashiorkor’.  The disease is most frequently found in children and infants in Africa and Central America. It is especially common in developing countries that are experiencing famine, political unrest and natural disasters. Consequences of Kwashiorkor include stunted growth, muscle and skin problems, impaired mental problems, immune system impairment, oedema.





(Oedema is a swell of abdomen and legs as plasma proteins responsible for controlling the tissue fluid are not projected and thus fluids build up.)




3. Phenylketonuria(PKU)

  Phenylketonuria(PKU) is a genetic mutation changes of the gene coding for tyrosine hydroxylase which is responsible for metabolizing phenylalanine in to tyrosine. Phenylalanine is instead converted into phenyl pyruvic acid; resulting in a high level of ketones in the blood and urine. Over time, this may result in brain damage or mental retardation.

  Diagnosis of phenylketonuria can be made by a simple blood test for the levels of phenylalanine. As PKU results in the build up of phenylalanine in the bloodstream, it is treated by following a special diet that is low in protein.
Diet should include fruits, grains, vegetables and special formula milk and must be undertaken from early in life or else symptoms will appear. Symptoms may include tremors, seizures, eczema, skin rashes and eventually brain damage (mental retardation)





4. Fatty acids

  Fatty acids all have the same general structure, but there maybe variation in the bonding between carbon atoms. Saturated fatty acids have no carbon double bonds while unsaturated fatty acids do have some double bonds between carbon atoms. The unsaturated fatty acids can be divided into mono-saturated with single double bond and poly-saturated with multiple double bonds. There is another variation as well: cis-isomers that hydrogen attached to the double bonded atoms are on the same side and trans-isomers that have hydrogen on opposite sides.

  All types of fatty acids consumed as part of dietary intake will cause weight gain and increase risks of hear disease if taken in excessive amounts. There are several different health effects of consuming different types of fatty acids explained below.







Saturated fatty acids
Unsaturated fatty acids



Cis-fats
Trans-fats
Sources
Animal fats, butter, milk, cheese
Vegetable oils, fish oils
Hydrogenated vegetable oils, margarine
Effects
1.         Raise harmful LDL cholesterol
2.         Leads to atherosclerosis and coronary heart disease(CHD)
3.         Promotes beneficial HDL cholesterol
4.        Inhibits harmful LDL cholesterol
5.         Omega-3 linked to brain development
6.         Significantly raises LDL cholesterol
7.         Strong links to atherosclerosis and CHD













Bibliography






A1.8~A1.14


Difference between Minerals and Vitamins
Minerals inorganic elements in ionic form – e.g. sodium (Na+), potassium (K+) and iodine (I)
Vitamins: organic compounds made by plants or animals – e.g. retinol (vitamin A) and calciferol (vitamin D)

How do we determine the recommended daily intake of vitamin C ?

Retrospective Research:
Ä An older method used was to: identify sufferers of vitamin C diseases and determine their levels of vitamin C.
Ä Unfortunately, this was an inexact method for determining dietary requirements as it was based on preventing disease, not promoting any further more cellular functions.

Clinical Trials:
Ä More recent attempts at determining the recommended daily intake of vitamin have involved through experimental studies
Ä This has included testing cell cultures, guinea pigs and finally humans.  
Ä The purpose of these tests are to identify cellular function and disease onset at different daily amount of vitamin C

How much vitamin C does an adult need to consume per day?
Higher intake gives protection against upper respiratory tract infections, and the danger of rebound malnutrition

Common sources of vitamin C: fruits, orange juice and vitamin C tablets
The recommended daily allowance (RDA) of vitamin C will be different between gender and age
The recommended daily intake (RDI) of vitamin C has been set at 65 – 90 mg
However, there is significant debate as to whether the daily intake should be higher (> 1000 mg), in order to achieve beneficial effects.

Some claim that higher doses of Vitamin C may boost the immune system, speed recovery from injury and protect against upper respiratory tract infections

Others suggest that taking larger doses would promote rebound malnutrition: the body changes to a larger intake and responds poorly whenever dosages drop back to normal levels

Vitamin D in human diets:
Cereal (fortified)
Oily fish (e.g. tuna)
Milk (fortified)
Egg (specifically yolk)
Liver
Yogurt

Balancing the risks from sunlight:

Ä UV light causes the skin to synthesize vitamin D, where it is stored in the liver for when UV levels are low
Ä Insufficient sun exposure may lead to skeletal deformities
Ä However high levels of UV light can damage skin cells and cause skin cancers
Ä Using sun block and covering skin with clothing will prevent UV radiation reaching the skin, inhibiting vitamin D production
Ä Certain diets (e.g. vegans, vegetarians) are lack of vitamin D, so that such people need more exposure to sunlight
Ä Individuals with darker skin pigmentation produce vitamin D more slowly, but protected the skin better
Ä Some people may be at a greater risk of vitamin D deficiency due to cultural or religious practices
Ä Having vitamin D in the diet can reduce the risk of vitamin D deficiency without requiring sun exposure

Vitamin D Deficiency Causing Rickets
A.1.13  The benefits of artificial dietary supplementation to prevent malnutrition

Ä Artificial supplementation ensures a group of people has sufficient access to essential nutrients, even when the natural dietary supply may be limited
Ä Iodine is necessary for thyroxine production and an iodine deficiency will enlarged thyroid and mental retardation
Ä Dietary supplementation is usually achieved through the production of iodised salt, as few foods are rich in iodine (like seafoods)


A.1.14  The importance of fibre

Dietary fibre is an important part of a balanced diet as it plays an important role in human health:
Ä It provides bulk in food, ensuring the continuous passage of materials through the digestive tract
Ä Stimulates peristaltic contractions to make the digestive system to pass food
Ä Helps regulate blood sugar and reduces blood cholesterol
Ä Lowers risk of appendicitis and intestinal cancer
Ä Helps prevent constipation